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Baseline characteristics
Values of demographic, clinical and
other variables collected for each participant at the beginning of a trial, before the intervention is administered.
Bias
[In statistics.] A systematic error
or deviation
in results or inferences from the truth. In studies of the
effects of health care, the main types of bias arise from systematic
differences in the groups that are compared (selection bias), the care
that is provided, exposure to other factors apart from the intervention of interest (performance bias),
withdrawals or exclusions of people entered into a study (attrition bias) or how
outcomes are assessed (detection
bias). Reviews of studies may also be particularly affected
by reporting bias,
where a biased subset of all the relevant data is available.
Bias
prevention
Aspects of the design or conduct of a
study designed to prevent bias.
For controlled trials,
such aspects include randomisation, blinding and concealment of allocation.
Blinding (synonym: masking)
[In a controlled
trial:]
The process of preventing those involved in a trial from knowing to
which comparison group a particular participant belongs. The risk of bias is minimised when as few people
as possible know who is receiving the experimental intervention and who the control intervention. Participants, caregivers, outcome assessors, and analysts
are all candidates for being blinded. Blinding of certain
groups
is not always possible, for example surgeons in surgical trials. The
terms single blind, double blind and triple blind are in common use,
but are not used consistently and so are ambiguous unless the specific
people who are blinded are listed. (Also called masking.)